华东师范大学学报(自然科学版) ›› 2010, Vol. 2010 ›› Issue (2): 77-81.

• 生命科学 • 上一篇    下一篇

葛根黄酮降血糖防治糖尿病并发症的实验研究

张再超，叶希韵,徐敏华，王耀发
   

  1. 华东师范大学 生命科学学院，上海 200062
  • 收稿日期:2008-12-19 修回日期:2009-04-07 出版日期:2010-03-25 发布日期:2010-03-25
  • 通讯作者: 叶希韵

Experimental study on the hypoglycemic action and prevention of diabetic complication with Pueraria flavonoids

ZHANG Zaicao，YE Xiyun,XU Minhua，WANG Yaofa   

  1. School of Life Science, East China Normal University, Shanghai 200062, China
  • Received:2008-12-19 Revised:2009-04-07 Online:2010-03-25 Published:2010-03-25
  • Contact: YE Xiyun

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摘要： 通过尾静脉注射四氧嘧啶（50 mg/kg体重）建立糖尿病小鼠模型，实验分为正常组、糖尿病组、糖脉康药物对照组和葛根黄酮组，实验40 d后检测各组动物体重、饮水量、血糖、糖耐量、果糖胺、山梨醇、醛糖还原酶、山梨醇脱氢酶和糖基化终产物（AGEs）等实验指标.结果表明,葛根黄酮能明显改善糖尿病小鼠的病理症状，降低血糖水平，降低血液中果糖胺、山梨醇、醛糖还原酶和AGEs的含量，升高血液中山梨醇脱氢酶的含量，同时还能降低肝脏、肾脏、大脑、心脏和皮肤组织中AGEs和山梨醇的含量，与糖尿病组小鼠比较差异显著（P<0.01）.由此得出结论，葛根黄酮除具有明显降血糖作用外，还对糖尿病并发症有一定的预防和治疗效果.

关键词: 葛根黄酮, 血糖, 糖尿病小鼠, 糖尿病并发症, 葛根黄酮, 血糖, 糖尿病小鼠, 糖尿病并发症

Abstract: An animal model of diabetes was established with alloxan tail vein injection (50 mg/kg), in order to research the effects of Pueraria flavonoids on blood glucose level and the prevention of diabetes and its complication. The mice were randomly divided into 4 groups: normal group, diabetic group, Tang Mai Kang control group and Pueraria flavonoids group. After 40 days, the weight, water intake, blood glucose, sugar tolerance, fructosamine, Dglucitol, aldose reductase, SDH and advanced glycation end products(AGEs) of the mice were detected. Compared with the diabetic group, the blood glucose〖JP2〗 level of the mice treated with Pueraria flavonoids was decreased markedly, while the content of SDH in the blood was increased significantly. The contents of fructosamine, Dglucitol, aldose reductase and AGEs in the blood were reduced obviously. Moreover, the contents of AGEs and Dglucitol in 〖JP〗the liver, kidney, cerebrum, heart and skin were also decreased (all P＜0.01).Our results demonstrate that Pueraria flavonoids are effective not only in lowering blood glucose level but also in the prevention or treatment diabetesinduced complication.

Key words: blood glucose, diabetic mice, diabetic complication, Pueraria flavonoids, blood glucose, diabetic mice, diabetic complication

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