天然产物: 农药新靶标与农药创制间的桥梁

doi:10.3969/j.issn.1000-5641.2023.01.003

华东师范大学学报（自然科学版） ›› 2023, Vol. 2023 ›› Issue (1): 21-30.doi: 10.3969/j.issn.1000-5641.2023.01.003

天然产物: 农药新靶标与农药创制间的桥梁

房正奇, 高栓虎, 何海兵*()

华东师范大学化学与分子工程学院上海市绿色化学与化工过程绿色化重点实验室, 上海　200062

收稿日期:2022-08-23 接受日期:2022-11-16 出版日期:2023-01-25 发布日期:2023-01-07
通讯作者: 何海兵 E-mail:hbhe@chem.ecnu.edu.cn

Natural products: A bridge between new targets and novel pesticide discovery

Zhengqi FANG, Shuanhu GAO, Haibing HE*()

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai　200062, China

Received:2022-08-23 Accepted:2022-11-16 Online:2023-01-25 Published:2023-01-07
Contact: Haibing HE E-mail:hbhe@chem.ecnu.edu.cn

摘要/Abstract

摘要：

农药的使用是控制作物病虫害、提高农作物产量的重要手段. 天然产物及其衍生物是农药的重要来源, 在杀虫、杀菌、植物生长调节、免疫调节等领域均发挥着重要作用. 随着基因组学、蛋白组学、结构生物学和其他生物技术的发展, 基于天然产物的农药靶标确证和基于靶标结构的新农药分子创制研究也得以飞速发展, 使得“合理设计”在农药创制研究中的应用凸显. 本文将通过案例, 展示基于已知靶标的活性天然产物的发现, 或基于天然产物的新农药靶标的确证, 以及其后续新农药创制的研究进展, 以阐释活性天然产物在新农药靶标与农药创制间的桥梁作用.

关键词: 农药, 天然产物, 生物靶点

Abstract:

Pesticides are important tools to control crop diseases and pest hazards, guaranteeing the crop harvest. Natural products and their derivatives are major sources of novel pesticides and play indispensable roles in various fields, such as insecticide, fungicide, plant growth regulation, immune regulation and so on. In recent years, numerous fields of biotechnology have made great progress, like genomics, proteomics and structural biology. And thus, the identification of pesticide targets based on natural products and the creation of novel pesticide molecules based on target structures developed rapidly. The concept, rational design, received more attention in pesticide creation. In this article, the discovery of active natural products based on existed targets or novel targets verifying by natural products were demonstrated by several cases, and the subsequent progress in the development of new pesticides were also discussed. The cases explained the important role of natural products in bridging new targets and novel pesticides.

Key words: pesticides, natural products, biological target

中图分类号:

S482.2

房正奇, 高栓虎, 何海兵. 天然产物: 农药新靶标与农药创制间的桥梁[J]. 华东师范大学学报（自然科学版）, 2023, 2023(1): 21-30.

Zhengqi FANG, Shuanhu GAO, Haibing HE. Natural products: A bridge between new targets and novel pesticide discovery[J]. Journal of East China Normal University(Natural Science), 2023, 2023(1): 21-30.

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天然产物: 农药新靶标与农药创制间的桥梁

Natural products: A bridge between new targets and novel pesticide discovery

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