Journal of East China Normal University(Natural Science) >
Progress and critical issues in research on micro- and nanoplastics in human body
Received date: 2024-08-06
Accepted date: 2024-09-29
Online published: 2024-11-29
Micro- and nanoplastics (M-NPs) are ubiquitous in the natural environment and have become a topic of concern. However, due to the lack of key data on human exposure to M-NPs, our understanding of the potential health risks posed by the entry of M-NPs into the human body is still limited. Current research indicates that M-NPs are commonly found in various parts of the human body. However, the experimental analysis techniques for M-NPs in the human body have not yet been standardized, with the main differences lying in sample pretreatment and detection methods. This increases the difficulty of conducting systematic research on the distribution, transfer, accumulation, and excretion of M-NPs in the human body. In addition, the study of nanoplastics (< 1 μm) still faces insurmountable technical obstacles. The experimental research results of M-NPs standard samples, although instructive, do not fully reflect the exposure risks of M-NPs in the real environment, and thus, do not have universal scientific significance. This review aims to provide direction for the standardization of experimental analysis and risk assessment for M-NPs in the human body.
Tiefeng CUI , Daoji LI . Progress and critical issues in research on micro- and nanoplastics in human body[J]. Journal of East China Normal University(Natural Science), 2024 , 2024(6) : 1 -13 . DOI: 10.3969/j.issn.1000-5641.2024.06.001
1 | SHARMA V K, MA X, LICHTFOUSE E, et al.. Nanoplastics are potentially more dangerous than microplastics. Environmental Chemistry Letters, 2023, 21 (4): 1933- 1936. |
2 | LUQMAN A, NUGRAHAPRAJA H, WAHYUONO R A, et al.. Microplastic contamination in human stools, foods, and drinking water associated with Indonesian coastal population. Environments, 2021, 8 (12): 138. |
3 | SCHYMANSKI D, GOLDBECK C, HUMPF H U, et al.. Analysis of microplastics in water by micro-Raman spectroscopy: Release of plastic particles from different packaging into mineral water. Water Research, 2018, 129, 154- 162. |
4 | DI FIORE C, SAMMARTINO M P, GIANNATTASIO C, et al.. Microplastic contamination in commercial salt: An issue for their sampling and quantification. Food Chemistry, 2023, 404, 134682. |
5 | BEAUREPAIRE M, DRIS R, GASPERI J, et al.. Microplastics in the atmospheric compartment: A comprehensive review on methods, results on their occurrence and determining factors. Current Opinion in Food Science, 2021, 41, 159- 168. |
6 | VETHAAK A D, LEGLER J.. Microplastics and human health. Science, 2021, 371 (6530): 672- 674. |
7 | ?A?LAYAN U, GüNDO?DU S, RAMOS T M, et al.. Intravenous hypertonic fluids as a source of human microplastic exposure. Environmental Toxicology and Pharmacology, 2024, 107, 104411. |
8 | LI P, LI Q, LAI Y, et al.. Direct entry of micro(nano)plastics into human blood circulatory system by intravenous infusion. iScience, 2023, 26 (12): 108454. |
9 | ZHU L, MA M, SUN X, et al.. Microplastics entry into the blood by infusion therapy: Few but a direct pathway. Environmental Science & Technology Letters, 2023, 11 (2): 67- 72. |
10 | HORVATITS T, TAMMINGA M, LIU B, et al.. Microplastics detected in cirrhotic liver tissue. eBioMedicine, 2022, 82, 104147. |
11 | RAGUSA A, NOTARSTEFANO V, SVELATO A, et al.. Raman microspectroscopy detection and characterisation of microplastics in human breastmilk. Polymers, 2022, 14 (13): 2700. |
12 | LESLIE H A, VAN VELZEN M J M, BRANDSMA S H, et al.. Discovery and quantification of plastic particle pollution in human blood. Environment International, 2022, 163, 107199. |
13 | 崔铁峰, 张杰, 卢灿然, 等.. 微塑料的测定方法以及对水生生物的生态毒理效应. 河北大学学报(自然科学版), 2024, 44 (1): 84- 91. |
14 | DENG Y, ZHANG Y, LEMOS B, et al.. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure. Scientific Reports, 2017, 7 (1): 46687. |
15 | GARCIA M M, ROMERO A S, MERKLEY S D, et al.. In vivo tissue distribution of polystyrene or mixed polymer microspheres and metabolomic analysis after oral exposure in mice. Environmental Health Perspectives, 2024, 132 (4): 47005. |
16 | HUANG S, HUANG X, BI R, et al.. Detection and analysis of microplastics in human sputum. Environmental Science & Technology, 2022, 56 (4): 2476- 2486. |
17 | AMATO-LOUREN?O L F, CARVALHO-OLIVEIRA R, JúNIOR G R, et al.. Presence of airborne microplastics in human lung tissue. Journal of Hazardous Materials, 2021, 416, 126124. |
18 | JENNER L C, ROTCHELL J M, BENNETT R T, et al.. Detection of microplastics in human lung tissue using μFTIR spectroscopy. Science of the Total Environment, 2022, 831, 154907. |
19 | CHEN Q, GAO J, YU H, et al.. An emerging role of microplastics in the etiology of lung ground glass nodules. Environmental Sciences Europe, 2022, 34 (1): 25. |
20 | BAEZA-MARTíNEZ C.. First evidence of microplastics isolated in European citizens’ lower airway. Journal of Hazardous Materials, 2022, 438, 129439. |
21 | ABBASI S, TURNER A.. Human exposure to microplastics: A study in Iran. Journal of Hazardous Materials, 2021, 403, 123799. |
22 | IBRAHIM Y S, TUAN ANUAR S, AZMI A A, et al.. Detection of microplastics in human colectomy specimens. JGH Open, 2021, 5 (1): 116- 121. |
23 | SCHWABL P, K?PPEL S, K?NIGSHOFER P, et al.. Detection of various microplastics in human stool: A prospective case series. Annals of Internal Medicine, 2019, 171 (7): 453- 457. |
24 | ZHANG J, WANG L, TRASANDE L, et al.. Occurrence of polyethylene terephthalate and polycarbonate microplastics in infant and adult feces. Environmental Science & Technology Letters, 2021, 8 (11): 989- 994. |
25 | YAN Z, ZHAO H, ZHAO Y, et al.. An efficient method for extracting microplastics from feces of different species. Journal of Hazardous Materials, 2020, 384, 121489. |
26 | YAN Z, LIU Y, ZHANG T, et al.. Analysis of microplastics in human feces reveals a correlation between fecal microplastics and inflammatory bowel disease status. Environmental Science & Technology, 2022, 56 (1): 414- 421. |
27 | WIBOWO A T, NUGRAHAPRAJA H, WAHYUONO R A, et al.. Microplastic contamination in the human gastrointestinal tract and daily consumables associated with an Indonesian farming community. Sustainability, 2021, 13 (22): 12840. |
28 | HO Y W, LIM J Y, YEOH Y K, et al.. Preliminary findings of the high quantity of microplastics in faeces of Hong Kong residents. Toxics, 2022, 10 (8): 414. |
29 | ZHU L, WU Z, DONG J, et al.. Unveiling small-sized plastic particles hidden behind large-sized ones in human excretion and their potential sources. Environmental Science & Technology, 2024, 58 (27): 11901- 11911. |
30 | RAGUSA A, SVELATO A, SANTACROCE C, et al.. Plasticenta: First evidence of microplastics in human placenta. Environment International, 2021, 146, 106274. |
31 | RAGUSA A, MATTA M, CRISTIANO L, et al.. Deeply in plasticenta: Presence of microplastics in the intracellular compartment of human placentas. International Journal of Environmental Research and Public Health, 2022, 19 (18): 11593. |
32 | ZHU L, ZHU J, ZUO R, et al.. Identification of microplastics in human placenta using laser direct infrared spectroscopy. Science of the Total Environment, 2023, 856, 159060. |
33 | BRAUN T, EHRLICH L, HENRICH W, et al.. Detection of microplastic in human placenta and meconium in a clinical setting. Pharmaceutics, 2021, 13 (7): 921. |
34 | MONTANO L, GIORGINI E, NOTARSTEFANO V, et al. Raman microspectroscopy evidence of microplastics in human semen[J]. Science of the Total Environment, 2023: 165922. |
35 | YANG Y, XIE E, DU Z, et al.. Detection of various microplastics in patients undergoing cardiac surgery. Environmental Science & Technology, 2023, 57 (30): 10911- 10918. |
36 | MARFELLA R, PRATTICHIZZO F, SARDU C, et al.. Microplastics and nanoplastics in atheromas and cardiovascular events. New England Journal of Medicine, 2024, 390 (10): 900- 910. |
37 | BRITS M, VAN VELZEN M J M, SEFILOGLU F ?, et al.. Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography–mass spectrometry. Microplastics and Nanoplastics, 2024, 4 (1): 1- 12. |
38 | WU D, FENG Y, WANG R, et al.. Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence. Journal of Advanced Research, 2023, 49, 141- 150. |
39 | ZHU L, KANG Y, MA M, et al.. Tissue accumulation of microplastics and potential health risks in human. Science of the Total Environment, 2024, 915, 170004. |
40 | ZHANG N, LI Y B, HE H R, et al.. You are what you eat: Microplastics in the feces of young men living in Beijing. Science of the Total Environment, 2021, 767, 144345. |
41 | RAGUSA A, SVELATO A, SANTACROCE C, et al. Plasticenta: Microplastics in human placenta [Z/OL]. (2020-07-15)[2024-09-30]. https://www.biorxiv.org/content/10.1101/2020.07.15.198325v1. |
42 | ZHENG X, FENG Q, GUO L.. Quantitative analysis of microplastics and nanoplastics released from disposable PVC infusion tubes. Journal of Hazardous Materials, 2024, 465, 133246. |
43 | CUI T, LIU K, ZHU L, et al.. Is Intravenous infusion an unrecognized route for internal microplastic human exposure? A general assessment. Journal of Hazardous Materials, 2024, 480, 135769. |
44 | EERKES-MEDRANO D, THOMPSON R C, ALDRIDGE D C.. Microplastics in freshwater systems: A review of the emerging threats, identification of knowledge gaps and prioritisation of research needs. Water Research, 2015, 75, 63- 82. |
45 | SENATHIRAJAH K, ATTWOOD S, BHAGWAT G, et al.. Estimation of the mass of microplastics ingested: A pivotal first step towards human health risk assessment. Journal of Hazardous Materials, 2021, 404, 124004. |
46 | BESSELING E, WANG B, LüRLING M, et al.. Nanoplastic affects growth of S. obliquus and reproduction of D. magna. Environmental Science & Technology, 2014, 48 (20): 12336- 12343. |
47 | CUI T, SHI W, WANG H, et al.. Standardizing microplastics used for establishing recovery efficiency when assessing microplastics in environmental samples. Science of the Total Environment, 2022, 827, 154323. |
48 | MOGHA N K, SHIN D.. Nanoplastic detection with surface enhanced Raman spectroscopy: Present and future. TrAC Trends in Analytical Chemistry, 2023, 158, 116885. |
49 | XU G, CHENG H, JONES R, et al.. Surface-enhanced Raman spectroscopy facilitates the detection of microplastics <1 μm in the environment. Environmental Science & Technology, 2020, 54 (24): 15594- 15603. |
50 | XIE L, GONG K, LIU Y, et al.. Strategies and challenges of identifying nanoplastics in environment by surface-enhanced Raman spectroscopy. Environmental Science & Technology, 2023, 57 (1): 25- 43. |
51 | BUTT H J, CAPPELLA B, KAPPL M.. Force measurements with the atomic force microscope: Technique, interpretation and applications. Surface Science Reports, 2005, 59 (1): 1- 152. |
52 | WEBB H K, TRUONG V K, HASAN J, et al.. Physico-mechanical characterisation of cells using atomic force microscopy: Current research and methodologies. Journal of Microbiological Methods, 2011, 86 (2): 131- 139. |
53 | VITALI C, PETERS R, JANSSEN H G, et al.. Microplastics and nanoplastics in food, water, and beverages, part Ⅱ. Methods. TrAC Trends in Analytical Chemistry, 2022, 157, 116819. |
/
〈 |
|
〉 |