前脑特异性过表达NR2B基因对小鼠社会互动能力的影响

华东师范大学学报(自然科学版) ›› 2012, Vol. 2012 ›› Issue (4): 75-82.

前脑特异性过表达NR2B基因对小鼠社会互动能力的影响

张宁¹，李春霞^1,2

1. 华东师范大学脑功能基因组学教育部重点实验室、上海市脑功能基因组学重点实验室，上海 200062；2. 华东师范大学认知神经科学研究所，上海 200062

收稿日期:2011-04-01 修回日期:2011-07-01 出版日期:2012-07-25 发布日期:2014-12-15

Effect of forebrain NR2B overexpression on social interactions in transgenic mice

ZHANG Ning ¹, LI Chun-xia ^1,2

1. Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China;
2. Institute of Cognitive Neuroscience, East China Normal University, Shanghai 200062, China

Received:2011-04-01 Revised:2011-07-01 Online:2012-07-25 Published:2014-12-15

摘要/Abstract

摘要： 将2～3月龄实验小鼠分为前脑NR2B过表达的转基因雌性和雄性小鼠以及同窝野生对照雌性和雄性小鼠，进行社会互动能力测试，包括新环境中的社会互动能力测试、社会交往能力和社会新奇偏好测试.结果显示，前脑NR2B表达量的提高，对NR2B转基因小鼠在新环境中的社会互动能力和社会新奇偏好无影响.但是却使得雌性NR2B转基因小鼠的社会交往能力提高，但是对雄性NR2B转基因小鼠却无明显影响.这表明，NR2B在前脑过量表达会提高雌性小鼠的社会交往能力，但对于雄性小鼠社会行为没有明显影响.

关键词: NR2B, 转基因小鼠, 社会互动, 社会交往能力, 社会新奇偏好

Abstract: Male and female NR2B transgenic mice and their littermate controls were subjected to the social interaction test in a novel environment, sociability test and social novelty test. There was no significant difference in social interaction test in a novel environment and social novelty test among these four groups. However, compared with wild type mice, female but not male NR2B transgenic mice exhibited improvement in sociability. These results suggest that NR2B overexpression in the forebrain can improve sociability of female mice, while having no significant effect on social behaviors in male mice.

Key words: NR2B, transgenic mice, social interaction, sociability, social novelty

中图分类号:

Q189

张宁，李春霞. 前脑特异性过表达NR2B基因对小鼠社会互动能力的影响[J]. 华东师范大学学报(自然科学版), 2012, 2012(4): 75-82.

ZHANG Ning, LI Chun-xia. Effect of forebrain NR2B overexpression on social interactions in transgenic mice[J]. Journal of East China Normal University(Natural Sc, 2012, 2012(4): 75-82.

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