Review Articles

Construction of D-optimal saturated designs for main effects and F1-second-order interactions in the presence of a free factor

Francois K. Domagni ,

kouakou-francois.domagni@csun.edu

Department of Mathematics, California State University, Northridge, California, USA

Yujia Zhang ,

Department of Mathematics, California State University, Northridge, California, USA

A. S. Hedayat

Department of Mathematics, Statistics, and Computer Science, University of Illinois at Chicago, Chicago, IL, USA

Pages | Received 04 Mar. 2025, Accepted 11 Jul. 2025, Published online: 21 Aug. 2025,
  • Abstract
  • Full Article
  • References
  • Citations

The allocation of resources in a 2𝑘-factorial experiment is crucial when the experimental resources are limited. In practice, when resources are limited, it is common for investigators to use all the information at their disposal to reduce the amount of resources needed for an experiment without trading the accuracy of the experiment. Suppose we have k + 1 factors and the investigator knows one of the factors (we call this factor an extra factor throughout the paper) does not interact with any of the remaining k factors. Furthermore, the investigator believes among the remaining k factors, one factor potentially interacts with the rest of the k−1 factors. In this paper, we show how a D-optimal saturated design can be constructed for this problem with the minimum number of runs. In the process, we show the investigator can even forgo the presence of the extra factor in certain runs without compromising the D-optimality of the saturated design.

References

  • Cohn, J. H. E. (1989). On determinants with elements ±1, II. Bulletin of the London Mathematical Society21(1), 36–42. https://doi.org/10.1112/blms/21.1.36
  • Cohn, J. H. E. (2000). Almost D-optimal designs. Utilitas Mathematica57, 121–128.
  • Domagni, F. K., Hedayat, A. S., & Sinha, B. K. (2024). D-optimal saturated designs for main effects and interactions in 2k-factorial experiments D-optimal saturated designs for main effects and interactions in 2k-factorial experiments. Statistical Theory and Related Fields8(3), 186–194. https://doi.org/10.1080/24754269.2024.2341983
  • Hedayat, A. S., & Pesotan, H. (1992). Two-level factorial designs for main-effects and selected two-factor interactions. Statistica Sinica2(2), 453–464.
  • Hedayat, A. S., & Pesotan, H. (2007). Tools for constructing optimal two-level factorial designs for a linear model containing main effects and one two-factor interaction. Journal of Statistical Planning and Inference137(4), 1452–1463. https://doi.org/10.1016/j.jspi.2006.04.005
  • Hedayat, A. S., & Zhu, H. (2011). An effective algorithm for searching for D-optimal saturated two-level factorial designs. Journal of Statistical Theory and Applications10(2), 209–227.
  • Heyden, Y. V., Jimidar, M., Hund, E., Niemeijer, N., Peeters, R., Smeyers-Verbeke, J., Massart, D. L., & Hoogmartens, J. (1999). Determination of system suitability limits with a robustness test. Journal of Chromatography A845(1-2), 145–154. https://doi.org/10.1016/S0021-9673(99)00328-3
  • Kiefer, J. (1959). Optimum experimental designs. Journal of the Royal Statistical Society, Series B21(2), 272–319. https://doi.org/10.1111/j.2517-6161.1959.tb00338.x
  • Orrick, W. P. (2005). The maximal {−1,1}-determinant of order 15. Metrika62(2-3), 195–219. https://doi.org/10.1007/s00184-005-0410-3
  • Phoa, F. K. H., Wong, W. K., & Xu, H. (2009). The need of considering the interactions in the analysis of screening designs. Journal of Chemometrics23(10), 545–553. https://doi.org/10.1002/cem.v23:10
  • Smith, W. D. (1988). Studies in Computational Geometry Motivated by Mesh Generation [Unpublished doctoral dissertation]. Princeton University.
  • Wald, A. (1943). On the efficient design of statistical investigations. Annals of Mathematical Statistics14(2), 134–140. https://doi.org/10.1214/aoms/1177731454

To cite this article: Francois K. Domagni, Yujia Zhang & A. S. Hedayat (21 Aug 2025): Construction of D-optimal saturated designs for main effects and F1-second-order interactions in the presence of a free factor, Statistical Theory and Related Fields, DOI: 10.1080/24754269.2025.2537504

To link to this article: https://doi.org/10.1080/24754269.2025.2537504