基于微液滴的 ZnO 纳米结构制备及荧光检测性能研究

doi:10.3969/j.issn.1000-5641.201933001

华东师范大学学报（自然科学版） ›› 2020, Vol. 2020 ›› Issue (2): 131-139.doi: 10.3969/j.issn.1000-5641.201933001

• 化学化工 • 上一篇

基于微液滴的 ZnO 纳米结构制备及荧光检测性能研究

黄斌冰, 谢琰, 谢文辉, 赵振杰, 李欣

华东师范大学物理与电子科学学院纳光电与先进装备教育部工程研究中心, 上海　200062

收稿日期:2019-04-03 发布日期:2020-03-16
通讯作者: 赵振杰,男,教授,博士生导师,研究方向为磁性材料与传感器.E-mail:zjzhao@phy.ecnu.edu.cn;李欣,女,副教授,硕士生导师,研究方向为微流控技术.E-mail:xli@phy.ecnu.edu.cn E-mail:zjzhao@phy.ecnu.edu.cn;xli@phy.ecnu.edu.cn
基金资助:
国家自然科学基金（11574084，11774091，11704122，51302085，51572086）

Preparation and fluorescence detection properties of ZnO nanostructure based on microdroplets

HUANG Binbing, XIE Yan, XIE Wenhui, ZHAO Zhenjie, LI Xin

Engineering Research Center for Nanophotonics and Advanced Instrument, School of Physics and Electronic Science, East China Normal University, Shanghai　200062, China

Received:2019-04-03 Published:2020-03-16

摘要/Abstract

摘要： 基于液滴微反应器, 通过水热法合成 ZnO 纳米结构. 该芯片集成了多种功能单元, 包括用于液滴生成的T形通道, 液滴汇合的 Y 形通道, 以及快速混合和观察纳米结构形成的 S 形通道. 通过调节水相和油相的流量改变液滴的尺寸, 研究微液滴中制备的纳米结构的形貌和尺寸, 并利用硫氰酸荧光素标记的羊抗牛 IgG 研究其荧光检测性能. 该工作表明, 通过流体动力学耦合形成的微液滴可制备 ZnO 纳米结构, 其颗粒形貌和尺寸随着液滴尺寸的变化而改变. 加热温度为 75 ℃, 油相、氨水、锌盐溶液流量分别为600、30、90 μL/h时制备的ZnO纳米结构具有最优的荧光检测性能.

关键词: 微流控芯片, 液滴, ZnO纳米结构, 荧光检测

Abstract: In this paper, we discuss ZnO nanostructures synthesized by a hydrothermal method in a droplet microreactor. The microfluidic chip used integrates a multi-function unit that includes a T-channel for droplet formation, a Y-channel for droplet fusion, and an S-channel for rapid mixing and observation of the nanoparticle formation process. By adjusting the flow rates of the aqueous phase and the oil phase, we studied the morphology and size of droplets; fluorescence detection of the ZnO nanostructure synthesized, moreover, was evaluated by an FITC-labeled goat anti-bovine IgG. This work shows that ZnO nanostructures can be prepared by fluid dynamic coupling of droplets and that the morphology and size of the nanostructures vary with droplet size. When the flow rates of the oil phase, ammonia water, and ferric solution were 600, 30, and 90 μL/h, respectively, the ZnO nanostructure synthesized at 75 ℃ showed optimal fluorescence detection performance.

Key words: microfluidic chip, droplet, ZnO nanostructure, fluorescence detection

中图分类号:

O611

黄斌冰, 谢琰, 谢文辉, 赵振杰, 李欣. 基于微液滴的 ZnO 纳米结构制备及荧光检测性能研究[J]. 华东师范大学学报（自然科学版）, 2020, 2020(2): 131-139.

HUANG Binbing, XIE Yan, XIE Wenhui, ZHAO Zhenjie, LI Xin. Preparation and fluorescence detection properties of ZnO nanostructure based on microdroplets[J]. Journal of East China Normal University(Natural Science), 2020, 2020(2): 131-139.

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基于微液滴的 ZnO 纳米结构制备及荧光检测性能研究

Preparation and fluorescence detection properties of ZnO nanostructure based on microdroplets

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