华东师范大学学报（自然科学版） ›› 2023, Vol. 2023 ›› Issue (1): 31-40.doi: 10.3969/j.issn.1000-5641.2023.01.004

• 原子经济性反应 • 上一篇    下一篇

二氧化碳作为C1合成子参与的手性杂环化合物的不对称催化合成研究

赵智鹏1, 孙莹1, 高小童2, 周锋1,3,*()   

  1. 1. 华东师范大学 化学与分子工程学院 上海市绿色化学与化工过程绿色化重点实验室, 上海　200062
    2. 重庆科技学院 化学化工学院, 重庆　401331
    3. 崇明生态研究院, 上海　202162
  • 收稿日期:2022-09-06 接受日期:2022-10-27 出版日期:2023-01-25 发布日期:2023-01-07
  • 通讯作者: 周锋 E-mail:fzhou@chem.ecnu.edu.cn
  • 基金资助:
    国家重点研发计划 (2020YFA0710200); 国家自然科学基金 (21871090); 中央高校基本科研业务费专项资金

Catalytic asymmetric synthesis of chiral heterocyclic compounds with CO2 as the C1 synthon

Zhipeng ZHAO1, Ying SUN1, Xiaotong GAO2, Feng ZHOU1,3,*()   

  1. 1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai　200062, China
    2. School of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing　401331, China
    3. Institute of Eco-Chongming, Shanghai　202162, China
  • Received:2022-09-06 Accepted:2022-10-27 Online:2023-01-25 Published:2023-01-07
  • Contact: Feng ZHOU E-mail:fzhou@chem.ecnu.edu.cn

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摘要：

二氧化碳是温室气体的主要成分, 也是廉价易得的可再生C1合成子. 其资源化利用不仅能够提供重要的基础化学品、能源产品及功能材料, 同时也是实现碳循环及减少碳排放的理想途径. 鉴于手性杂环化合物在有机合成和药物研发中的重要性, 近年来发展以二氧化碳为合成子的绿色高效和高立体选择性的直接构建手性杂环化合物的方法受到了广泛关注, 已经发展了合成手性内酯、环碳酸酯以及环氨基甲酸酯的方法. 本文拟概括相关领域的研究进展.

关键词: 二氧化碳, 不对称催化合成, 手性杂环化合物

Abstract:

As the main component of greenhouse gases, CO2 represents an inexpensive and readily available renewable C1 synthon. In the past few decades, great efforts have been made toward the development of chemical processes that use CO2 as a promising fossil fuel alternative for C1 feedstocks for the production of industrially attractive chemicals. This could provide access to materials of commercial interest from an abundant, nontoxic, renewable, and low-cost carbon source, thus offering interesting opportunities for the chemical industry, organic synthesis, and so on. Considering the importance of chiral heterocycles in organic synthesis and drug development, the development of highly stereoselective and efficient catalytic asymmetric reactions using CO2 as a C1 synthon for these chiral heterocycles has received considerable attention. Successful examples for chiral lactones, carbonates, and carbamates have already been demonstrated. In this paper, we summarize the recent advances in this field.

Key words: carbon dioxide, catalytic asymmetric synthesis, chiral heterocyclic compounds

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