华东师范大学学报(自然科学版) ›› 2008, Vol. 2008 ›› Issue (2): 64-70.

• 生命科学 • 上一篇    下一篇

刺激大鼠杏仁外侧核对听皮层神经元调频声反应的影响

陈福俊1，何德富2，周绍慈1   

  1. 1. 华东师范大学 生命科学学院,上海200062； 2. 华东师范大学 环境科学系，上海200062
  • 收稿日期:2006-12-20 修回日期:2007-02-07 出版日期:2008-03-25 发布日期:2008-03-25
  • 通讯作者: 周绍慈

Influence of the lateral nucleus of amygdala stimulation on the auditory responses to frequency-modulated sound in auditory cortex(Chinese)

CHEN Fu-jun1,HE De-fu2,ZHOU Shao-ci1   

  1. 1. School of Life Science, East China Normal University, Shanghai 200062, China;2. Department of Environmental Science, East Normal University, Shanghai 200062, China
  • Received:2006-12-20 Revised:2007-02-07 Online:2008-03-25 Published:2008-03-25
  • Contact: ZHOU Shao-ci

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摘要： 采用在体细胞外单细胞记录方法，研究电刺激杏仁外侧核对调频声所诱发的听皮层神经元反应的影响.实验在34只乌拉坦麻醉的SD大鼠上进行，在皮层41区记录了113个对调频声有反应的细胞电活动.观察发现，这些神经元对调频声刺激的反应可分为ON反应，OFF反应，ON-OFF反应，持续性反应和给声抑制反应几种类型.在观察对其中42个神经元的声反应时给予了杏仁外侧核电刺激，其中22%的神经元反应被易化，48%的神经元反应受到了抑制，另外30%神经元的声反应未受杏仁外侧核刺激的影响.这些影响进一步表明，杏仁复合体可在皮层水平参与听觉上传信息的处理，包括听觉信息的加工与整合.同时也表明杏仁核在上传听觉信息的筛选中可能具有重要的作用.

关键词: 杏仁核, 听皮层, 调频声, 声反应, 调制, 杏仁核, 听皮层, 调频声, 声反应, 调制

Abstract: The aim of this study is to investigate the influence of the lateral nucleus of amygdala stimulation on the auditory response in the auditory cortex evoked by frequency-modulated sound. The experiments were performed on 34 urethane anesthetized SD rats using extracellular recording. 113 auditory neurons were recorded in the cortical area 41. The auditory response pattern includes ON response, OFF response, ON-OFF response, sustained response and suppression of the spontaneous discharge. 42 neurons were recorded with the amygdala stimulation. The results showed that the facilitated and inhibitory effects were 22% and 48% respectively. The other 30% of recorded neurons has no change to the stimulation. The influence of the amygdala on the auditory response indicated that the amygdala can engage in the auditory ascending information process and integration in the cortex level. It suggests that the amygdala may have an important role in the selection of the auditory ascending information.

Key words: auditory cortex, frequency-modulated sound, auditory response, modulation, amygdala, auditory cortex, frequency-modulated sound, auditory response, modulation

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