华东师范大学学报(自然科学版) ›› 2011, Vol. 2011 ›› Issue (6): 132-138.

• 化学化工 • 上一篇    下一篇

强极性化合物DMC及其杂质的HILIC分离方法研究

韩冰冰， 王翠翠， 李新军， 邹新琢   

  1. 华东师范大学 化学系，上海 200062
  • 收稿日期:2010-12-01 修回日期:2011-03-01 出版日期:2011-11-25 发布日期:2011-11-22

Research on separation method of highly polar compound DMC and impurities in it by HILIC

HAN Bing-bing, WANG Cui-cui, LI Xin-jun, ZOU Xin-zhuo   

  1. Department of Chemistry, East China Normal University, Shanghai 200062, China
  • Received:2010-12-01 Revised:2011-03-01 Online:2011-11-25 Published:2011-11-22

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摘要： 建立以亲水作用色谱法对强极性化合物甲基丙烯酰氧乙基三甲基氯化铵（DMC）及其杂质进行分离分析的方法.使用Sepax HP-Cyano和X-Bridge HILIC两种不同的亲水作用色谱柱，以乙腈和水为流动相进行梯度洗脱，高效快速地实现了DMC及其所含杂质的分离分析.通过这两种色谱柱，共可以分离出甲基丙烯酸二甲氨基乙酯（DM）、甲基丙烯酸（MAA）、三甲基羟乙基氯化铵（CC）和对羟基苯甲醚（MQ）4种杂质.该方法具有较好的实用价值，能有效地应用于强极性化合物的分离和分析中.

关键词: 亲水作用色谱, 甲基丙烯酰氧乙基三甲基氯化铵, 强极性化合物, 分离

Abstract: HILIC method was established to separate and analyze highly polar compound methacryloyloxyethyl trimethyl ammonium chloride (DMC) and its impurities. Using two different chromatographic columns：HP-Cyano column and X-Bridge HILIC column，highly polar compound DMC and its impurities were all well separated by gradient elution using acetonitrile and water as mobile phase. With the two different chromatographic columns, four impurities in DMC were separated, such as dimethylaminoethyl methacrylate (DM),methacrylic acid (MAA), choline chloride (CC) and Hydroquinone monomethyl ether (MQ). This method has higher practical value, which can be used effectively in separated highly polar compounds.

Key words: hydrophilic interaction liquid chromatography (HILIC), methacryloyloxyethyl trimethyl ammonium chloride (DMC), highly polar compounds, separation

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