蛋白酶体激活因子REGγ的肿瘤相关靶蛋白研究进展

doi:10.3969/j.issn.1000-5641.2018.02.013

华东师范大学学报(自然科学版) ›› 2018, Vol. 2018 ›› Issue (2): 125-130,159.doi: 10.3969/j.issn.1000-5641.2018.02.013

蛋白酶体激活因子REGγ的肿瘤相关靶蛋白研究进展

陈少军¹, 李晓涛², 郑军华¹

1. 同济大学附属上海市第十人民医院泌尿外科, 上海 200072;
2. 华东师范大学生命医学研究所, 上海 200241

收稿日期:2017-02-20 出版日期:2018-03-25 发布日期:2018-03-22
通讯作者: 郑军华,男,教授,研究方向为泌尿系统肿瘤的基础及临床研究.E-mail:zhengjh0471@sina.com. E-mail:zhengjh0471@sina.com
作者简介:陈少军,男,博士研究生.研究方向为泌尿系统肿瘤的基础及临床研究.E-mail:urochen@163.com.
基金资助:
国家自然科学基金（81602216）

Research progress of the target proteins by proteasome activator REGγ in human cancers

CHEN Shao-jun¹, LI Xiao-tao², ZHENG Jun-hua¹

1. Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China;
2. Institute of Biomedical Sciences, East China Normal University, Shanghai 200241, China

Received:2017-02-20 Online:2018-03-25 Published:2018-03-22

摘要/Abstract

摘要： 蛋白酶体激活因子REGγ属于蛋白酶体激活因子REG（又名11 S）家族的成员之一，主要是通过激活20 S蛋白酶体以非泛素化和非ATP依赖的方式降解蛋白质.近年来，越来越多的研究表明，REGγ在多种肿瘤中出现了异常表达并与肿瘤的发生发展密切相关.REGγ主要是通过降解多种靶蛋白并调控相关的信号通路参与肿瘤的发生发展.本文综述了REGγ在肿瘤中发挥作用的靶蛋白，旨在进一步了解REGγ参与肿瘤发生发展的机制并揭示其作为人类多种肿瘤的诊断标志物和治疗靶点的潜在可能性.

关键词: REG&gamma, 肿瘤, 靶蛋白

Abstract: The proteasome activator REGγ, which is a member of REG (11 S) proteasome activator family, can stimulate the proteolytic activity of the 20 S core proteasome to degrade proteins independent of ubiquitination and ATP. In recent years, more and more studies show that REGγ is dysregulated in various human cancers and closely related to the oncogenesis and development of cancers. The potential mechanism by which REGγ exerts its role in cancer development is degradation of various target proteins. We now review the target proteins of REGγ in human cancers in order to further understand the mechanism by which REGγ exerts its role in cancer development, and to uncover the potential of REGγ to serve as a new marker for diagnosis and a novel target for treatment in human cancers.

Key words: REGγ, cancer, target proteins

中图分类号:

O157.5

陈少军, 李晓涛, 郑军华. 蛋白酶体激活因子REGγ的肿瘤相关靶蛋白研究进展[J]. 华东师范大学学报(自然科学版), 2018, 2018(2): 125-130,159.

CHEN Shao-jun, LI Xiao-tao, ZHENG Jun-hua. Research progress of the target proteins by proteasome activator REGγ in human cancers[J]. Journal of East China Normal University(Natural Sc, 2018, 2018(2): 125-130,159.

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蛋白酶体激活因子REGγ的肿瘤相关靶蛋白研究进展

Research progress of the target proteins by proteasome activator REGγ in human cancers

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