华东师范大学学报(自然科学版) ›› 2023, Vol. 2023 ›› Issue (1): 50-59.doi: 10.3969/j.issn.1000-5641.2023.01.006

• 绿色功能材料 • 上一篇    下一篇

糖基绿色功能材料自组装及性能研究

豆伟涛(), 徐林*(), 杨海波*()   

  1. 华东师范大学 化学与分子工程学院 上海市绿色化学与化工过程绿色化重点实验室, 上海 200062
  • 收稿日期:2022-07-04 接受日期:2022-09-23 出版日期:2023-01-25 发布日期:2023-01-07
  • 通讯作者: 徐林,杨海波 E-mail:douweitao123@163.com;lxu@chem.ecnu.edu.cn;hbyang@chem.ecnu.edu.cn
  • 作者简介:豆伟涛, 男, 博士, 副研究员, 研究方向为超分子化学生物学. E-mail: douweitao123@163.com
  • 基金资助:
    国家自然科学基金 (21922506, 92056203)

Recent progress in the construction and application of self-assembled glycomaterials

Weitao DOU(), Lin XU*(), Haibo YANG*()   

  1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
  • Received:2022-07-04 Accepted:2022-09-23 Online:2023-01-25 Published:2023-01-07
  • Contact: Lin XU,Haibo YANG E-mail:douweitao123@163.com;lxu@chem.ecnu.edu.cn;hbyang@chem.ecnu.edu.cn

摘要:

糖作为生命体内重要的信号分子, 与受体间的特异性识别往往介导着重要的生理和病理学过程, 因此, 构筑功能性糖基靶向材料成为解密和调控糖生物学功能的重要途径. 由于其组装简单、结构可控的优势, 糖基功能性材料可通过非共价作用的超分子自组装策略简易获得. 本文系统总结了通过主客体相互作用和配位键导向自组装这两种超分子自组装策略构筑糖基组装材料的方法与应用. 最后, 强调了潜在挑战和未来方向, 希望推动糖基纳米材料的发展及更深入地了解碳水化合物相关的生理和病理过程.

关键词: 自组装, 主客体作用, 配位键导向自组装, 糖基材料

Abstract:

As essential signaling molecules in biological systems, carbohydrates are involved in several vital physiological and pathological processes via specific recognition by receptors. Hence, nanomaterials comprising carbohydrates are crucial for deciphering and regulating biological processes. A non-covalent assembly process can conveniently yield carbohydrate-based nanomaterials owing to the unique merits of simplicity and controllability of the process. This review summarizes the construction and application of glyco-based functional materials through host-guest interactions and coordination-driven self-assembly processes. Additionally, their potential challenges and future directions are highlighted with the aim of improving understanding on carbohydrate-related physiological and pathological processes.

Key words: self-assembly, host-guest interaction, coordination-driven self-assembly, glycomaterials

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