华东师范大学学报(自然科学版) ›› 2008, Vol. 2008 ›› Issue (2): 78-84.

• 生命科学 • 上一篇    下一篇

桑黄粗多糖对肿瘤细胞增殖及转移相关能力的抑制作用

赵澜，张红锋   

  1. 华东师范大学 生命科学学院，上海200062
  • 收稿日期:2007-03-01 修回日期:2007-05-21 出版日期:2008-03-25 发布日期:2008-03-25
  • 通讯作者: 张红锋

Inhibitory effects of polysaccharides extracted from phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37(Chinese)

ZHAO Lan，ZHANG Hong-feng   

  1. School of Life Science, East China Normal University, Shanghai200062, China
  • Received:2007-03-01 Revised:2007-05-21 Online:2008-03-25 Published:2008-03-25
  • Contact: ZHANG Hong-feng

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摘要： 研究了桑黄粗多糖（PL）对高转移卵巢癌细胞（HO-8910PM）和乳腺癌细胞（Bcap-37）增殖和转移相关能力的影响及其作用的机制.研究结果表明,桑黄粗多糖能有效抑制裸鼠移植瘤的生长，抑制率为65.37%；对离体培养的HO-8910PM和Bcap-37细胞的抑制率分别达到15.53%和23.81%；500 ind/ml PL作用于HO-8910PM细胞96 h可诱导其凋亡，通过细胞周期G0/G1期阻滞而抑制细胞增殖和诱导细胞凋亡；PL能显著抑制HO-8910PM的黏附、侵袭和迁移等肿瘤转移相关能力.桑黄粗多糖具有抑制肿瘤细胞增殖及肿瘤转移的作用.

关键词: 桑黄多糖, 高转移卵巢癌细胞, 乳腺癌细胞, 增殖, 转移, 桑黄多糖, 高转移卵巢癌细胞, 乳腺癌细胞, 增殖, 转移

Abstract: This paper studied the effects and mechanism of polysaccharides extracted from Phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37.The results showed PL inhibited the growth of Bcap37 tumor in vivo by 65.37%, while inhibited the proliferation of HO-8910PM and Bcap-37 in vitro respectively by 15.53% and 23.81%.PL induced G0/G1 phase arrest and 500 ind/ml PL induced HO-8910PM cell apoptosis after 96 h treatments.PL may act as a direct inhibitor of HO-8910PM cell adhesion, invasion and migration which are related to tumor metastasis.The result indicated that PL has inhibitory effect on tumor cell proliferation and metastasis.

Key words: HO-8910PM, Bcap-37, proliferation, metastasis, polysaccharides from Phellinus linteus, HO-8910PM, Bcap-37, proliferation, metastasis

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