一种新型T1-T2双模磁共振造影剂的制备及性能研究

华东师范大学学报(自然科学版) ›› 2013, Vol. 2013 ›› Issue (5): 102-109.

一种新型T1-T2双模磁共振造影剂的制备及性能研究

高礼鹏¹，刘凯¹，罗春花²，李建奇³，王依婷¹，彭晖²

1. 华东师范大学科学与技术跨学科高等研究院, 上海 200062；2. 华东师范大学极化材料与器件教育部重点实验室, 上海 200241；3. 华东师范大学物理系, 上海 200062

收稿日期:2013-03-01 修回日期:2013-06-01 出版日期:2013-09-25 发布日期:2013-09-30

Preparation and properties study of a new type of T1-T2 dual mode MRI contrast agent

GAO Li-peng¹, LIU Kai¹, LUO Chun-hua², LI Jian-qi³,WANG Yi-ting¹, PENG Hui²

1. Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai 200062, China;
2. Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, China;
3. Department of physics, East China Normal University, Shanghai 200062, China

Received:2013-03-01 Revised:2013-06-01 Online:2013-09-25 Published:2013-09-30

摘要/Abstract

摘要： 研究了Fe₃O₄ @ SiO₂ @ Gd₂O(CO₃)₂核/壳/壳磁性纳米粒子,作为一种新型的T1-T2双模磁共振成像造影剂.并对这种纳米粒子的细胞活性进行了体外细胞毒性试验(MTT). 结果显示其具有良好的生物相容性,有望成为一种新型双模磁共振造影剂.

关键词: Fe₃O₄ @ SiO₂ @ Gd₂O(CO₃)₂核/壳/壳纳米粒子, 双模磁共振造影剂, 生物相容性

Abstract: This paper studied the Fe₃O₄ @ SiO₂ @ Gd₂O(CO₃)₂ core/shell/shell NPs as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging. The magnetic coupling between Gd₂O(CO₃)₂ and Fe₃O₄ was modulated by the separating SiO₂ layer to produce appropriate T1 and T2 signal. The Fe₃O₄ @ SiO₂ @ Gd₂O(CO₃)₂ NPs exhibit good biocompatibility, showing great potential for biomedical applications.

Key words: Fe₃O₄ @ SiO₂ @ Gd₂O(CO₃)₂ core/shell/shell NPs, dual model contrast agent, biocompatibility

中图分类号:

O469

高礼鹏，刘凯，罗春花，李建奇，王依婷，彭晖. 一种新型T1-T2双模磁共振造影剂的制备及性能研究[J]. 华东师范大学学报(自然科学版), 2013, 2013(5): 102-109.

GAO Li-peng, LIU Kai, LUO Chun-hua, LI Jian-qi,WANG Yi-ting, PENG Hui. Preparation and properties study of a new type of T1-T2 dual mode MRI contrast agent[J]. Journal of East China Normal University(Natural Sc, 2013, 2013(5): 102-109.

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