华东师范大学学报(自然科学版) ›› 2006, Vol. 2006 ›› Issue (2): 1-6.

• 化学 •    下一篇

新颖杂环类维A酸的合成及其生物活性

陈 震, 王 静, 徐字金, 邹新琢   

  1. 华东师范大学 化学系,上海 200062
  • 收稿日期:2005-04-07 修回日期:2005-04-22 出版日期:2006-03-25 发布日期:2006-03-25
  • 通讯作者: 邹新琢

Syntheses and Biological Activity of Novel Heteroretinoids(Chinese)

CHEN Zhen, WANG Jing, XU Zi-jin, ZOU Xin-zhuo   

  1. Department of Chemistry, East China Normal University, Shanghai 200062, China
  • Received:2005-04-07 Revised:2005-04-22 Online:2006-03-25 Published:2006-03-25
  • Contact: ZOU Xin-zhuo

摘要:

三种结构新颖的杂环类维A酸,即 5-四甲基四氢萘基-3-吡唑甲酸,2-甲基-5-四甲基四氢萘基-3-呋喃甲酸,1-丁基-2-甲基-5-四甲基四氢化萘基-3-吡咯甲酸的合成被报道.生物活性测试表明它们对肿瘤细胞(HL-60)有一定的抑制作用.

关键词: 维A酸, 杂环, 合成, 生物活性, 维A酸, 杂环, 合成, 生物活性

Abstract:

Syntheses of three novel heteroretinoids were reported. Novel heteroretinoids were 5-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3-pyrazole carboxylic acid, 2-Methyl -5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-furan-3-carboxylic acid, 1-Butyl -2-methyl-5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-1H-pyrrole-3-carboxylic acid.The results of biological test indicated that these compounds possessed some growth inhibition effects in leukemia cells.

Key words: heterocycle, synthesis, biological activity, heteroretinoid, heterocycle, synthesis, biological activity

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