Expressions of REGγ, p53, NOTCH1 and BRAF gene in thyroid cancer and their clinical relevance

Journal of East China Normal University(Natural Sc ›› 20120, Vol. 2012 ›› Issue (6): 89-95.doi:

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Expressions of REG_γ, p53, NOTCH1 and BRAF gene in thyroid cancer and their clinical relevance

QI Long ¹ , ZUO Di ²， WANG Hui ¹ , LI Xiao-tao ²

1. Department of Nuclear Medicine， Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine，Shanghai 200092, China； 2. Institute of Biomedical Sciences，East China Normal University， Shanghai 200241, China

Received:2012-01-01 Revised:2012-04-01 Online:2012-11-25 Published:2013-01-11

Abstract

Abstract: This study was designed to investigate the expressions of〖WTBX〗 REGγ〖WTBZ〗,〖WTBX〗〖STBX〗p53〖WTBZ〗, 〖WTBX〗NOTCH1〖WTBZ〗 and 〖WTBX〗BRAF〖WTBZ〗 in papillary thyroid cancer as well as the potential correlations with clinicopathological significance. The expressions of 〖WTBX〗REGγ〖WTBZ〗,〖WTBX〗 p53〖WTBZ〗,〖WTBX〗 NOTCH1〖STBZ〗〖WTBZ〗 and 〖WTBX〗BRAF〖WTBZ〗 in thyroid cancer samples were detected by Realtime-PCR and immunohistochemistry, respectively. The correlations with clinicopathological factors were statistically analyzed. The expression of 〖WTBX〗REGγ〖WTBZ〗 in papillary thyroid cancer samples was significantly higher, with an 87.5% (35/40) positive rate in cancer tissues, and was correlated with age and lymph node status (〖WTBX〗P〖WTBZ〗=0.015 1<0.05), but not related to sex (〖WTBX〗P〖WTBZ〗=0.742>0.05). In addition, the 〖WTBX〗REGγ〖WTBZ〗 had a positive correlation with the levels of 〖WTBX〗〖STBX〗p53, NOTCH1〖STBZ〗〖WTBZ〗 and 〖WTBX〗BRAF〖WTBZ〗 (〖WTBX〗P〖WTBZ〗=0.023 3<0.05), indicating that 〖WTBX〗REGγ〖WTBZ〗 could serve as an objective biological-marker for estimating the occurrence and progression of papillary thyroid cancer. Combined detection of 〖WTBX〗〖STBX〗p53〖WTBZ〗,〖WTBX〗 NOTCH1〖WTBZ〗 and 〖WTBX〗BRAF 〖WTBZ〗may facilitate clinical diagnosis, treatment and prediction of prognosis.

Key words: thyroid cancer, p53, NOTCH1, REG_γ, BRAF

CLC Number:

R736.1

QI Long, ZUO Di， WANG Hui, LI Xiao-tao . Expressions of REG_γ, p53, NOTCH1 and BRAF gene in thyroid cancer and their clinical relevance[J]. Journal of East China Normal University(Natural Sc, 20120, 2012(6): 89-95.

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Expressions of REG_γ, p53, NOTCH1 and BRAF gene in thyroid cancer and their clinical relevance

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