Journal of East China Normal University(Natural Sc ›› 2019, Vol. 2019 ›› Issue (3): 131-137.doi: 10.3969/j.issn.1000-5641.2019.03.014

• Life Science • Previous Articles     Next Articles

Effect of egg yolk immunoglobulin on an experimental periodontitis model induced by Porphyromonas gingivalis

WANG Fang1,2, XU Xiao-chen3, WU Wen-hui2,4   

  1. 1. College of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China;
    2. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;
    3. Shanghai MAXAM Company Limited, Shanghai 200333, China;
    4. Institute of Marine Science, Shanghai Ocean University, Shanghai 201306, China
  • Received:2018-05-11 Online:2019-05-25 Published:2019-05-30

Abstract: This study evaluates the therapeutic effects of egg yolk Immunoglobulin (IgY) on periodontitis in an established rat periodontitis model through the growth inhibition of Porphyromonas gingivalis. Experimental periodontitis was induced in mice by ligation of their second molar with medical thread and oral infection with Porphyromonas gingivalis. Periodontitis rats were randomly divided into control, high-dose, and low-dose groups. Each group was comprised of eight rats. The gingival index (GI), plaque index (PI), and bleeding on probing (BOP) were evaluated, the levels of IL-6 and TNF-α were examined, and an X-ray image and histomorphological section were observed after 28 days. Compared with the control, the scores for PI, GI, and BOP and the levels of IL-6 and TNF-α were significantly decreased in the IgY-treated groups. X-ray images showed that the tooth gap narrowed considerably. Pathological observation, furthermore, showed that periodontal fibers were neatly arranged, a small amount of inflammatory cells were infiltrated, the alveolar ridge was not absorbed, and alveolar bone increased. In conclusion, specific IgY can treat periodontitis induced by P.gingivalis in an established rat periodontitis model.

Key words: egg yolk immunoglobulin, IgY, experimental periodontitis model, periodontal index, IL-6, TNF-α, X-ray, histomorphology

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