Journal of East China Normal University(Natural Sc ›› 2018, Vol. 2018 ›› Issue (2): 125-130,159.doi: 10.3969/j.issn.1000-5641.2018.02.013

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Research progress of the target proteins by proteasome activator REGγ in human cancers

CHEN Shao-jun1, LI Xiao-tao2, ZHENG Jun-hua1   

  1. 1. Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China;
    2. Institute of Biomedical Sciences, East China Normal University, Shanghai 200241, China
  • Received:2017-02-20 Online:2018-03-25 Published:2018-03-22

Abstract: The proteasome activator REGγ, which is a member of REG (11 S) proteasome activator family, can stimulate the proteolytic activity of the 20 S core proteasome to degrade proteins independent of ubiquitination and ATP. In recent years, more and more studies show that REGγ is dysregulated in various human cancers and closely related to the oncogenesis and development of cancers. The potential mechanism by which REGγ exerts its role in cancer development is degradation of various target proteins. We now review the target proteins of REGγ in human cancers in order to further understand the mechanism by which REGγ exerts its role in cancer development, and to uncover the potential of REGγ to serve as a new marker for diagnosis and a novel target for treatment in human cancers.

Key words: REGγ, cancer, target proteins

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