Long-term potentiation of prefrontal cortex in NR1 knockout mice

Abstract

Abstract: This study investigated the prefrontal synaptic plasticity of forebrain-specific NR1 knockout mice by using the vitro field potential recording technique. The results from the input-output and paired pulse depression curves suggest that the basal synaptic transmission is normal in the prefrontal cortex of NR1 knockout mice. Prefrontal long-term potentiation (LTP) induced by high frequency stimulation (two trains of 100 Hz with 1 s duration and 30 s interval) was abolished in slices of NR1 knockout mice. These results indicate that NR1 is critical in the induction of long-term potentiation in prefrontal cortex.

Key words: N-methyl-D-aspartic acid receptor, prefrontal cortex, long-term potentiation

CLC Number:

Q189

YANG Li-guo, ZENG Qing-wen, ZHANG Xu-liang, CAO Xiao-hua. Long-term potentiation of prefrontal cortex in NR1 knockout mice[J]. Journal of East China Normal University(Natural Sc, 2012, 2012(1): 47-53.

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