Journal of East China Normal University(Natural Sc ›› 2010, Vol. 2010 ›› Issue (4): 103-110.

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SKF83959 regulates locomotion activity and anxiety in rats

DU Dan, ZHANG Shuang, DONG Su-zhen   

  1. Key Laboratories of MOE and STCSM, Shanghai Institute of Brain Functional Genomics, East China Normal University, Shanghai 200062, China
  • Received:2009-04-01 Revised:2009-08-01 Online:2010-07-25 Published:2010-07-25
  • Contact: DONG Su-zhen

Abstract: To investigate the effects of the selective agonist of dopamine D1-like receptors SKF83959 in locomotion activity, anxiety, and learning and memory,3monthold male rats were randomly divided into two groups:drugadministrated group in which SKF83959 was injected (i.p. 1.0 mg/kg), and control group in which PBS buffer with equivalent volume was employed instead of SKF83959. Behavioral tests were then conducted. SKF83959 administration induced a significant increase in both total move times and total move time, as revealed by open field test. In elevated plus maze test, rats in drugadministrated group exhibited much longer time staying in the close arms, with significant decreases in entries to total arms, the open arms and the close arms. However, fear conditioning test showed no difference in fear memory between drugadministrated group and control group. The results indicate that SKF83959 can enhance the locomotion and anxiety. However, it does not affect the fear memory in rats.

Key words: dopamine receptor, locomotion activity, SKF83959, anxiety, dopamine receptor, locomotion activity, SKF83959

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