Journal of East China Normal University(Natural Sc ›› 2011, Vol. 2011 ›› Issue (4): 94-103,123.

• Article • Previous Articles     Next Articles

αCaMKII overexpressions enhance excitatory synaptic transmission in insular cortex of mice

LIU Ru-qing, DUAN Yan-hong, CAO Xiao-hua   

  1. Key Laboratories of MOE and STCSM Shanghai, Institute of Brain Functional Genomics,East China Normal University, Shanghai 200062, China
  • Received:2010-04-01 Revised:2010-07-01 Online:2011-07-05 Published:2011-11-12

Abstract: The experiment was designed to study basic electrophysiological characteristics and basal synaptic transmission of insular pyramidal cells in αCaMKII forebrain overexpression mice by patch clamping. The basic electrophysiological results showed that there were no significant differences in the resting membrane potential, action potential and I-V curve of pyramidal cells in insular cortex between wild type and transgenic mice. No significant difference was measured in the frequency of sEPSCs and mEPSCs. However, compared to the wild type mice, transgenic mice exhibited augmented amplitude of sEPSCs and mEPSCs. There was also no significant difference in PPF curve. The results suggested that forebrain specific overexpression of αCaMKII did not change the basic electrophysiological characteristics and presynaptic transmitter release in insular cortex. The influence of αCaMKII overexpression on the amplitude of EPSCs may be mediated by postsynaptic receptors.

Key words: αCaMKII, Insular cortex, EPSCs

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