Journal of East China Normal University(Natural Science) ›› 2023, Vol. 2023 ›› Issue (1): 1-11.doi: 10.3969/j.issn.1000-5641.2023.01.001

• Atomic Economic Reactions •    

Recent advances in regioselective hydrodifluoroalkylation of alkenes

Ying ZHANG, Ling LIAO, Xiaosi HU, Jian ZHOU, Jinsheng YU*()   

  1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
  • Received:2022-08-18 Accepted:2022-11-01 Online:2023-01-25 Published:2023-01-07
  • Contact: Jinsheng YU


The regioselective hydrodifluoroalkylation of alkenes has been identified as a straightforward and highly atom-economical approach for synthesizing value-added difluoroalkylated molecules that have important applications in the pharmaceutical and agrochemical industries, as well as in the field of materials science. This is because olefins are structurally diverse raw materials that are inexpensive and easily obtainable from a wide range of sources. Recent years have witnessed significant progress in this field with the rapid development of visible-light catalysis and novel difluoroalkylating reagents. This article review summarizes the latest advances in the regioselective anti-Markovnikov and Markovnikov hydrodifluoroalkylation of various olefins, which provides an inspirational locale for researchers to engage. Herein, we supplement ideas for designing and developing new reactions, difluoroalkyl reagents, and catalytic strategies.

Key words: alkenes, regioselectivity, hydrodifluoroalkylation

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