Journal of East China Normal University(Natural Science) ›› 2023, Vol. 2023 ›› Issue (1): 104-113.doi: 10.3969/j.issn.1000-5641.2023.01.011

• Catalytic Reaction Technologies • Previous Articles    

Progress in synthesis of methyl glyoxylate by selective oxidation of methyl glycolate with molecular oxygen

Hao WANG1, Guofeng ZHAO1, Yong LU1,2,*()   

  1. 1. Shanghai Key Laboratory of Green Chemistry and Green Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
    2. Institute of Eco-Chongming, Shanghai 202162, China
  • Received:2022-06-15 Accepted:2022-11-07 Online:2023-01-25 Published:2023-01-07
  • Contact: Yong LU


Methyl glyoxylate is widely used in organic synthesis and chemical production. The application of traditional preparation methods is limited by high cost, low efficiency, and significant environmental pollution. During the coal to ethylene glycol process, methyl glycolate is produced as an intermediate product of the hydrogenation of dimethyl oxalate (DMO) to ethylene glycol. Methyl glycolate can be selectively obtained from DMO via hydrogenation, and therefore, has the potential to serve as raw material for methyl glyoxylate. However, only few studies have considered this process. Herein , the applications, traditional preparation methods, and state-of-the-art research progress of methyl glycolate oxidation are reviewed. Recent research on selective oxidation of related alcohols (such as ethanol) to aldehydes and ketones is also summarized.

Key words: methyl glycolate, methyl glyoxylate, selective oxidation, molecular oxygen, alcohol oxidation

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