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    Biomedical applications of synthetic nucleic acid engineering
    Mengyao CAO, Li LI, Hao PEI
    Journal of East China Normal University(Natural Science)    2023, 2023 (1): 177-185.   DOI: 10.3969/j.issn.1000-5641.2023.01.018
    Abstract213)   HTML10)    PDF (1728KB)(78)      

    The simple rule of base-pairing of nucleic acids enables nucleic acid structures to be designed via powerful energy-based prediction tools. Thus, nucleic acid structures have attracted considerable attention owing to their ability to fold into a variety of synthetic structures. However, the lack of chemical diversity of nucleic acid bases makes nucleic acid structures less functionally diverse than proteins, thereby limiting their practical applications. This review focuses on the underlying technology of nucleic acid molecular engineering, especially on the studies of nucleic acid structures and their molecular interactions. As nucleic acid structures are fully spatially addressable, a diversity of particles could be linked to designated positions on the surface of nucleic acid structures. Additionally, the intermolecular reaction kinetics of nucleic acids could be continuously fine-tuned by rational design of nucleic acid sequences. This review also summarizes the development of synthetic molecular networks, dynamic molecular machines, and nucleic acid-based biomaterials, as well as the application of these as green biomedical devices in biomolecular recognition, cell surface engineering, and biocatalysis.

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    Preparation and photothermal studies on a cucurbit[8]uril-based near-infrared organic supramolecular photothermal agent
    Wenyan CAI, Yue PAN, Qiwei ZHANG, Yang TIAN
    Journal of East China Normal University(Natural Science)    2023, 2023 (1): 186-193.   DOI: 10.3969/j.issn.1000-5641.2023.01.019
    Abstract223)   HTML10)    PDF (2397KB)(95)      

    Photothermal therapy has attracted attention as a novel cancer treatment with high specificity, minimal invasiveness, and low toxicity. In this study, a facile, effective, and green method was developed to prepare a novel supramolecular photothermal material. Grinding a commercial dye, dibenzotetrathiafulvalene (DBTTF, with absorption <400 nm) with cucurbit[8]uril (CB[8]) in air with a small amount of water leads to the oxidation of DBTTF to radical cations. Furthermore, DBTTF dimerizes, assembles into the cavity of CB[8], and forms a ternary supramolecular complex with strong absorption in the visible and near-infrared regions, where the longest absorption wavelength exceeds 1000 nm. The photothermal conversion efficiency of the supramolecular system is 18.7%. The system exhibits good photothermal stability and biocompatibility, and has been successfully applied in the photothermal ablation of live tumor cells. This supramolecular material has potential applications in photothermal therapy and other photothermal conversion fields.

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