Journal of East China Normal University(Natural Science) ›› 2023, Vol. 2023 ›› Issue (1): 31-40.doi: 10.3969/j.issn.1000-5641.2023.01.004

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Catalytic asymmetric synthesis of chiral heterocyclic compounds with CO2 as the C1 synthon

Zhipeng ZHAO1, Ying SUN1, Xiaotong GAO2, Feng ZHOU1,3,*()   

  1. 1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
    2. School of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
    3. Institute of Eco-Chongming, Shanghai 202162, China
  • Received:2022-09-06 Accepted:2022-10-27 Online:2023-01-25 Published:2023-01-07
  • Contact: Feng ZHOU


As the main component of greenhouse gases, CO2 represents an inexpensive and readily available renewable C1 synthon. In the past few decades, great efforts have been made toward the development of chemical processes that use CO2 as a promising fossil fuel alternative for C1 feedstocks for the production of industrially attractive chemicals. This could provide access to materials of commercial interest from an abundant, nontoxic, renewable, and low-cost carbon source, thus offering interesting opportunities for the chemical industry, organic synthesis, and so on. Considering the importance of chiral heterocycles in organic synthesis and drug development, the development of highly stereoselective and efficient catalytic asymmetric reactions using CO2 as a C1 synthon for these chiral heterocycles has received considerable attention. Successful examples for chiral lactones, carbonates, and carbamates have already been demonstrated. In this paper, we summarize the recent advances in this field.

Key words: carbon dioxide, catalytic asymmetric synthesis, chiral heterocyclic compounds

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