Journal of East China Normal University(Natural Sc ›› 2010, Vol. 2010 ›› Issue (2): 77-81.
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ZHANG Zaicao,YE Xiyun,XU Minhua,WANG Yaofa
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Abstract: An animal model of diabetes was established with alloxan tail vein injection (50 mg/kg), in order to research the effects of Pueraria flavonoids on blood glucose level and the prevention of diabetes and its complication. The mice were randomly divided into 4 groups: normal group, diabetic group, Tang Mai Kang control group and Pueraria flavonoids group. After 40 days, the weight, water intake, blood glucose, sugar tolerance, fructosamine, Dglucitol, aldose reductase, SDH and advanced glycation end products(AGEs) of the mice were detected. Compared with the diabetic group, the blood glucose〖JP2〗 level of the mice treated with Pueraria flavonoids was decreased markedly, while the content of SDH in the blood was increased significantly. The contents of fructosamine, Dglucitol, aldose reductase and AGEs in the blood were reduced obviously. Moreover, the contents of AGEs and Dglucitol in 〖JP〗the liver, kidney, cerebrum, heart and skin were also decreased (all P<0.01).Our results demonstrate that Pueraria flavonoids are effective not only in lowering blood glucose level but also in the prevention or treatment diabetesinduced complication.
Key words: blood glucose, diabetic mice, diabetic complication, Pueraria flavonoids, blood glucose, diabetic mice, diabetic complication
CLC Number:
R587.1
ZHANG Zaicao;YE Xiyun;XU Minhua;WANG Yaofa. Experimental study on the hypoglycemic action and prevention of diabetic complication with Pueraria flavonoids[J]. Journal of East China Normal University(Natural Sc, 2010, 2010(2): 77-81.
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