Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers

Abstract

Abstract: All of the publications were eligible from Medline and Pubmed databases and the information about relationship between CYP1A1 Ile462Val and Msp1 polymorphisms and lung cancer risk among smokers was summarized. Meta-analysis was performed using RevMan 4.2. 29 case-control studies were available. For Ile462Val, meta-analysis revealed that the risk of lung cancer among smokers with Val/Val and Ile/Val genotypes was 1.29 times of those with Ile/Ile genotype (P<0.05) by the random effects model. There was no significant correlation between Msp1 and lung cancer among smokers or non-smokers. These results suggest that CYP1A1 Ile462Val polymorphism is related to the susceptibility of lung cancer among smokers.

Key words: lung cancer, CYP1A1, polymorphisms, meta-analysis

CLC Number:

R734.2

CAI Yan-yan, TAN Xiao-ming, ZHENG Hong-xia, GU Hai-ying, ZHAN Xiao-ying, WU Qi-han. Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers[J]. Journal of East China Normal University(Natural Sc, 2011, 2011(4): 115-123.

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[1]	CAI Yan-yan, TAN Xiao-ming, ZHENG Hong-xia, GU Hai-ying, ZHAN Xiao-ying, WU Qi-han. Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers [J]. Journal of East China Normal University(Natural Sc, 0, (): 115-123.
[2]	CAI Yan-yan, TAN Xiao-ming, ZHENG Hong-xia, GU Hai-ying, ZHAN Xiao-ying, WU Qi-han. Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers [J]. Journal of East China Normal University(Natural Sc, 0, (): 115-123.