βCaMKII overexpression impairs long-term depression in dentate gyrus of mice

Abstract

Abstract: This experiment was designed to investigate the effects of the βCaMKII on the long-term depression (LTD) in dentate gyrus（DG）by using the transgenic mice in which the overexpression of βCaMKII is restricted to the DG area. Compared to the control group, the paired-pulse depression curve and voltage-current response in DG of transgenic mice didn’t change, but the LTD was significantly reduced. These results suggest that overexpression of the βCaMKII may impair the long-term depression without effect on the presynaptic function and passive properties of granule cells in DG area.

Key words: βCaMKII, dentate gyrus, long-term depression

CLC Number:

Q189

XU Hao, WANG Bo, DUAN Yan-hong, CAO Xiao-hua. βCaMKII overexpression impairs long-term depression in dentate gyrus of mice[J]. Journal of East China Normal University(Natural Sc, 2012, 2012(1): 54-62.

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