Journal of East China Normal University(Natural Sc ›› 2015, Vol. 2015 ›› Issue (6): 108-116.doi: 10.3969/j.issn.1000-5641.2015.06.014

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Effects of curcumin on oxidative stress status and thefunctions of astrocytes in the brain of aged rats

 ZHANG  Pan, YU  Bin, LIU  Sha, DUAN  Ya-Le, ZHAO  Zheng   

  • Received:2014-09-12 Online:2015-11-25 Published:2015-12-23

Abstract: The change of oxidative balance and astrocyte in the cortex and hippocampus of aged SD rats were investigated by Western blotting, enzyme assay, immunofluorescence and HPLCMS. The data showed that curcumin reduced the level of MDA and 8OHdG and enhanced the level of GSH and GCS activity, which indicated that curcumin inhibited the oxidative damage in the brian; the detection of the level of glial fibrillary acidic protein (GFAP) indicated curcumin inhibited the excessive activation of astrocytes and also the results of the activity of GS, the level of GDNF and Dserine showed that curcumin improved the function of astrocytes.

Key words: curcumin, aging, oxidative stress, astrocyte

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