Abstract: An animal model of diabetes was established with alloxan tail vein injection (50 mg/kg), in order to research the effects of Pueraria flavonoids on blood glucose level and the prevention of diabetes and its complication. The mice were randomly divided into 4 groups: normal group, diabetic group, Tang Mai Kang control group and Pueraria flavonoids group. After 40 days, the weight, water intake, blood glucose, sugar tolerance, fructosamine, Dglucitol, aldose reductase, SDH and advanced glycation end products(AGEs) of the mice were detected. Compared with the diabetic group, the blood glucose〖JP2〗 level of the mice treated with Pueraria flavonoids was decreased markedly, while the content of SDH in the blood was increased significantly. The contents of fructosamine, Dglucitol, aldose reductase and AGEs in the blood were reduced obviously. Moreover, the contents of AGEs and Dglucitol in 〖JP〗the liver, kidney, cerebrum, heart and skin were also decreased (all P＜0.01).Our results demonstrate that Pueraria flavonoids are effective not only in lowering blood glucose level but also in the prevention or treatment diabetesinduced complication.

Key words: blood glucose, diabetic mice, diabetic complication, Pueraria flavonoids, blood glucose, diabetic mice, diabetic complication