Journal of East China Normal University(Natural Sc ›› 2008, Vol. 2008 ›› Issue (2): 78-84.

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Inhibitory effects of polysaccharides extracted from phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37(Chinese)

ZHAO Lan,ZHANG Hong-feng   

  1. School of Life Science, East China Normal University, Shanghai200062, China
  • Received:2007-03-01 Revised:2007-05-21 Online:2008-03-25 Published:2008-03-25
  • Contact: ZHANG Hong-feng

Abstract: This paper studied the effects and mechanism of polysaccharides extracted from Phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37.The results showed PL inhibited the growth of Bcap37 tumor in vivo by 65.37%, while inhibited the proliferation of HO-8910PM and Bcap-37 in vitro respectively by 15.53% and 23.81%.PL induced G0/G1 phase arrest and 500 ind/ml PL induced HO-8910PM cell apoptosis after 96 h treatments.PL may act as a direct inhibitor of HO-8910PM cell adhesion, invasion and migration which are related to tumor metastasis.The result indicated that PL has inhibitory effect on tumor cell proliferation and metastasis.

Key words: HO-8910PM, Bcap-37, proliferation, metastasis, polysaccharides from Phellinus linteus, HO-8910PM, Bcap-37, proliferation, metastasis

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